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Dawley Inc extensor digitorum longus edl muscle graft
Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor <t>digitorum</t> longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative <t>EDL</t> weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.
Extensor Digitorum Longus Edl Muscle Graft, supplied by Dawley Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/edl+muscles/digitorum+edl+extensor+graft+longus+muscle/pmc12799798-72-12-5
Average 86 stars, based on 1 article reviews
extensor digitorum longus edl muscle graft - by Bioz Stars, 2026-10
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1) Product Images from "Directed functional reinnervation to curb nociception and enable sensation"

Article Title: Directed functional reinnervation to curb nociception and enable sensation

Journal: iScience

doi: 10.1016/j.isci.2025.114431

Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor digitorum longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative EDL weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.
Figure Legend Snippet: Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor digitorum longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative EDL weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.

Techniques Used: Control

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Activity Assay:

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Article Snippet: The AMP-activated protein kinase (AMPK) pathway participates in the metabolic effects of contraction on muscle glucose uptake.. We have shown that contraction increases both GLUT4 translocation to the cell surface and p38 mitogen-activated protein kinase (p38 MAPK) activity.. The latter pathway may be involved in the activation of GLUT4.

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Article Snippet: The euglycemic-hyperinsulinemic clamp technique in conscious Sprague-Dawley and Wistar rats chronically instrumented with intravascular catheters and pulsed Doppler flow probes was used to examine insulin’s actions on regional blood flow and glucose metabolism.. The effect of insulin on in vivo and in vitro glucose utilization in individual muscles was estimated using [H]-2-deoxy-D-glucose.. We found that in both strains, insulin (4, 32, and 64 mU · kg · min) causes similar cardiovascular changes characterized by slight increases in blood pressure (at high dose), vasodilation in renal and hindquarter vascular beds, and vasoconstriction (at high dose) in the superior mesenteric vascular bed.

In Vivo:

Article Title: The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle.
Article Snippet: The AMP-activated protein kinase (AMPK) pathway participates in the metabolic effects of contraction on muscle glucose uptake.. We have shown that contraction increases both GLUT4 translocation to the cell surface and p38 mitogen-activated protein kinase (p38 MAPK) activity.. The latter pathway may be involved in the activation of GLUT4.

Injection:

Article Title: The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle.
Article Snippet: The AMP-activated protein kinase (AMPK) pathway participates in the metabolic effects of contraction on muscle glucose uptake.. We have shown that contraction increases both GLUT4 translocation to the cell surface and p38 mitogen-activated protein kinase (p38 MAPK) activity.. The latter pathway may be involved in the activation of GLUT4.

Isolation:

Article Title: Effects of insulin on regional blood flow and glucose uptake in Wistar and Sprague-Dawley rats.
Article Snippet: The euglycemic-hyperinsulinemic clamp technique in conscious Sprague-Dawley and Wistar rats chronically instrumented with intravascular catheters and pulsed Doppler flow probes was used to examine insulin’s actions on regional blood flow and glucose metabolism.. The effect of insulin on in vivo and in vitro glucose utilization in individual muscles was estimated using [H]-2-deoxy-D-glucose.. We found that in both strains, insulin (4, 32, and 64 mU · kg · min) causes similar cardiovascular changes characterized by slight increases in blood pressure (at high dose), vasodilation in renal and hindquarter vascular beds, and vasoconstriction (at high dose) in the superior mesenteric vascular bed.

Article Title: Myotoxicity studies of O/W-in situ forming microparticle systems.
Article Snippet: The objective of this study was to investigate the myotoxicity potential of the solvents used in the preparation of polymer solutions and O/W-in situ forming microparticle (ISM) systems.. The acute myotoxicity studies of the tested solvents, emulsions of the solvents, polymer solutions as well as the O/W-ISM formulations with varying phase ratios were investigated using the in vitro isolated rodent skeletal muscle model by measuring the cumulative creatine kinase (CK) efflux.. Phenytoin and isotonic sodium chloride solution served as positive and negative controls, respectively.



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Image Search Results


Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor digitorum longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative EDL weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.

Journal: iScience

Article Title: Directed functional reinnervation to curb nociception and enable sensation

doi: 10.1016/j.isci.2025.114431

Figure Lengend Snippet: Construction of sensory RPNIs (A) Schematic of the surgical procedure wherein a sensory nerve and its neurovascular bundle are transected and used to neurotize a free muscle graft that is harvested. (B) The extensor digitorum longus was neurotized by the saphenous nerve. (C) Graft appearance after reinnervation, 6 weeks postoperative. (D) Changes in length and mass after 4–8 weeks of reinnervation. Percentages expressed as changes from preoperative EDL weight. (Control, gray; red, RPNI). Each data point represents measurements from one animal.

Article Snippet: Eleven male and two female Sprague-Dawley rats underwent RPNI construction using an extensor digitorum longus (EDL) muscle graft reinnervated by the saphenous neurovascular bundle.

Techniques: Control